Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | the regulatory domain of PKC leading to activation, and H2O2 activates PKC via increased phosphorylation of tyrosine in its catalytic domain | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
expression of UGT isozymes in COS-1 cells with co-localization of isozyme UGT1A7His and PKCepsilon and of isoyzme UGT1A10His andPKCalpha orPKCgamma | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
calphostin-C | - |
Homo sapiens | |
curcumin | reversable by low glucuronidation activity with curcumin as substrate, overview | Homo sapiens | |
additional information | inhibition of UGT activity by PKCepsilon-specific antagonist peptide or by PKCapsilon-targeted destruction with PKCepsilon-specific small interference RNA and activation of curcumin-down-regulated UGTs with typical PKC agonists verify a central PKC role in glucuronidation, overview. UGT down-regulation by the tyrosine kinase-specific inhibitor, herbimycin-A, suggests cellular oxidant-/H2O2-activated PKC via tyrosine phosphorylation also plays a role in sustaining UGT activity | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
endoplasmic reticulum | co-localization of UGTs with protein kinases C, overview | Homo sapiens | 5783 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
UDP-D-glucuronate + acceptor | Homo sapiens | protein kinases are involved in UGT regulation, UGTs inactivate aromatic-like metabolites and a vast number of dietary and environmental chemicals, which reduces the risk of toxicities, mutagenesis, and carcinogenesis, primarily in liver, kidney, and gastrointestinal tract, overview | UDP + acceptor beta-D-glucuronoside | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
phosphoprotein | UGT isozymes are phosphorylated by active protein kinases Cepsilon, Calpha, and Cgamma, analysis of UGT phosphorylation, overview | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
colon | - |
Homo sapiens | - |
gastrointestinal tract | - |
Homo sapiens | - |
kidney | - |
Homo sapiens | - |
liver | - |
Homo sapiens | - |
LS-180 cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | specific phospho-groups in UGT1A7 determine substrate selections, suggests regulated phosphorylation allows adaptations regarding differential phosphate utilization by UGTs to function efficiently | Homo sapiens | ? | - |
? | |
UDP-D-glucuronate + 4-nitrophenol | - |
Homo sapiens | UDP + 4-nitrophenyl beta-D-glucuronoside | - |
? | |
UDP-D-glucuronate + 5alpha-androstane-3alpha,17beta-diol | - |
Homo sapiens | UDP + ? | - |
? | |
UDP-D-glucuronate + acceptor | - |
Homo sapiens | UDP + acceptor beta-D-glucuronoside | - |
? | |
UDP-D-glucuronate + acceptor | protein kinases are involved in UGT regulation, UGTs inactivate aromatic-like metabolites and a vast number of dietary and environmental chemicals, which reduces the risk of toxicities, mutagenesis, and carcinogenesis, primarily in liver, kidney, and gastrointestinal tract, overview | Homo sapiens | UDP + acceptor beta-D-glucuronoside | - |
? | |
UDP-D-glucuronate + anthraflavic acid | - |
Homo sapiens | UDP + ? | - |
? | |
UDP-D-glucuronate + apigenin | - |
Homo sapiens | UDP + apigenin 7-O-beta-D-glucuronoside | - |
? | |
UDP-D-glucuronate + bilirubin | - |
Homo sapiens | UDP + ? | - |
? | |
UDP-D-glucuronate + capsaicin | - |
Homo sapiens | UDP + capsaicin beta-D-glucuronoside | - |
? | |
UDP-D-glucuronate + curcumin | low activity, can reverse the inhibitory effect of curcumin on UGTs | Homo sapiens | UDP + curcumin beta-D-glucuronoside | - |
? | |
UDP-D-glucuronate + estriol | - |
Homo sapiens | UDP + estriol 3-O-beta-D-glucuronoside | - |
? | |
UDP-D-glucuronate + eugenol | - |
Homo sapiens | UDP + eugenol beta-D-glucuronoside | - |
? | |
UDP-D-glucuronate + phenolphthalein | - |
Homo sapiens | UDP + phenolphthalein beta-D-monoglucuronoside | - |
? | |
UDP-D-glucuronate + phloretin | - |
Homo sapiens | UDP + ? | - |
? |
Subunits | Comment | Organism |
---|---|---|
? | x * 52000-55000, SDS-PAGE | Homo sapiens |
Synonyms | Comment | Organism |
---|---|---|
UDP-glucuronosyltransferase | - |
Homo sapiens |
UGT | - |
Homo sapiens |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Homo sapiens |
pH Minimum | pH Maximum | Comment | Organism |
---|---|---|---|
6.4 | 7.6 | - |
Homo sapiens |